Interrelationship Among Aging, Cancer and Differentiation: Proceedings of the Eighteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, April 29–May 2, 1985

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A. Pullman, Paul O.P. Ts'O, Edward L. Schneider
Springer Science & Business Media, 2012 M12 6 - 345 pages
In 1980. a distinguished group of scientists gathered In Washington. D. C. for an International Symposium on Aging and Cancer. Among the recommendations of this Symposium was to convene a future meeting to discuss the molecular basis for Interrelationships between aging and cancer when the appropriate scientific knowledge was available. That same year. the 13th Jerusalem Symposium on Quantum Chemistry and Biochemistry entitled ·Carcl nogenesls : Fundamental Mechanisms and Environmental Effects·. was held. attended by some 50 International authorities In this field. At this meeting. It became clear that the fundamental process of carcinogenesis 15 Intimately associated with differentiation. which must also be mechanistically related to aging. It was therefore proposed that the next Jerusalem Symposium on Cancer could provide the appropriate forum for the study on the Interrelationship among cancer. aging and differentiation. The Impressive advances In our knowledge of the nature of the genome through molecular genetic and physical chemical techniques have now provided the opportunity to examine the Interrelationships between these complex biolo gical processes. Through the Isolation. cloning and rearranging of genes we are able to dissect and manipulate the genome In a fashion that was unanticipated only a decade ago. At the same time. the Increase In longevity and the Increased numbers of Individuals entering the last decades of life where cancer Incidences are highest raise the profound and practical question of whether aging and cancer are linked through common mechanisms.

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Contents

H J COHEN Clinical Aspects of Cancer in the Elderly
15
MARTIN Overview of the Pathobiology of Aging 23
35
G B PIERCE and R S WELLS Cancer Cells as Probes of Embryonic
59
S H YUSPA Alterations in Epidermal Differentiation in Skin Carcino
80
J A MOSHIER R A MORGAN and R C C HUANG Expression
100
R T SCHIMKE Methotrexate Resistance Gene Amplification
117
J R SMITH and O M PEREIRASMITH Dominance of in Vitro
133
E KESHET A ITIN and G ROTMAN Retroviruslike Gene Families
149
P S MILLER C H AGRIS L AURELIAN K R BLAKE S B LIN
215
J WHANGPENG E LEE C S KAOSHAN R BOCCIA
233
BOREK Critical Molecular Events and Gene Regulation
255
F RAJEWSKY J ADAMKIEWICZ N HUH A KINDLERROHRBORN
267
S B PRUSINER Structure and Biology of Scrapie Prions 277
289
H PIETTE Ageing and Cancer A Common Free Radical
300
P P CARBONE C BEGG and J MOORMAN Cancer in
313
Cellular studies on
324

WANG DNA Supercoiling and Gene Expression T 73
182

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