Interrelationship Among Aging, Cancer and Differentiation: Proceedings of the Eighteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, April 29–May 2, 1985A. Pullman, Paul O.P. Ts'O, Edward L. Schneider Springer Science & Business Media, 2012 M12 6 - 345 pages In 1980. a distinguished group of scientists gathered In Washington. D. C. for an International Symposium on Aging and Cancer. Among the recommendations of this Symposium was to convene a future meeting to discuss the molecular basis for Interrelationships between aging and cancer when the appropriate scientific knowledge was available. That same year. the 13th Jerusalem Symposium on Quantum Chemistry and Biochemistry entitled ·Carcl nogenesls : Fundamental Mechanisms and Environmental Effects·. was held. attended by some 50 International authorities In this field. At this meeting. It became clear that the fundamental process of carcinogenesis 15 Intimately associated with differentiation. which must also be mechanistically related to aging. It was therefore proposed that the next Jerusalem Symposium on Cancer could provide the appropriate forum for the study on the Interrelationship among cancer. aging and differentiation. The Impressive advances In our knowledge of the nature of the genome through molecular genetic and physical chemical techniques have now provided the opportunity to examine the Interrelationships between these complex biolo gical processes. Through the Isolation. cloning and rearranging of genes we are able to dissect and manipulate the genome In a fashion that was unanticipated only a decade ago. At the same time. the Increase In longevity and the Increased numbers of Individuals entering the last decades of life where cancer Incidences are highest raise the profound and practical question of whether aging and cancer are linked through common mechanisms. |
From inside the book
Results 1-5 of 87
Page vi
... Normal Cells : Potential for Affecting Cellular Gene Expression 133 143 149 D. A. PEARLMAN , S.R. HOLBROOK and S. H. KIM / The Conforma- tional Effects of UV Induced Damage on DNA 163 J. C. WANG / DNA Supercoiling and Gene Expression ...
... Normal Cells : Potential for Affecting Cellular Gene Expression 133 143 149 D. A. PEARLMAN , S.R. HOLBROOK and S. H. KIM / The Conforma- tional Effects of UV Induced Damage on DNA 163 J. C. WANG / DNA Supercoiling and Gene Expression ...
Page 3
... normal cell growth and differentiation . The Type II oncogenes , such as myc oncogene , appear to be involved in the first step of cellular transformation converting cells with limited lifespans to the phenotype of unlimited replication ...
... normal cell growth and differentiation . The Type II oncogenes , such as myc oncogene , appear to be involved in the first step of cellular transformation converting cells with limited lifespans to the phenotype of unlimited replication ...
Page 22
... normal and abnormal structure and function . Nowhere is the overlap greater than in biogerontology . The dissociation of normative aging from " disorders " of aging is a major delemma that resists any facile resolutions . One such ...
... normal and abnormal structure and function . Nowhere is the overlap greater than in biogerontology . The dissociation of normative aging from " disorders " of aging is a major delemma that resists any facile resolutions . One such ...
Page 30
... normal , physiologic or adaptive changes in gene expression or of the differentiated state may be accompanied by alterations in gene structure . This can vary from the comparatively subtle and reversible inversion associated with phase ...
... normal , physiologic or adaptive changes in gene expression or of the differentiated state may be accompanied by alterations in gene structure . This can vary from the comparatively subtle and reversible inversion associated with phase ...
Page 31
... normal somatic cells . The latter is manifested by the gradual clonal attenutation of replicative potential ( Martin et al , 1984 ) . While it certainly would seem reasonable that certain somatic cell types ( eg . , epidermal basal ...
... normal somatic cells . The latter is manifested by the gradual clonal attenutation of replicative potential ( Martin et al , 1984 ) . While it certainly would seem reasonable that certain somatic cell types ( eg . , epidermal basal ...
Contents
15 | |
MARTIN Overview of the Pathobiology of Aging 23 | 35 |
G B PIERCE and R S WELLS Cancer Cells as Probes of Embryonic | 59 |
S H YUSPA Alterations in Epidermal Differentiation in Skin Carcino | 80 |
J A MOSHIER R A MORGAN and R C C HUANG Expression | 100 |
R T SCHIMKE Methotrexate Resistance Gene Amplification | 117 |
J R SMITH and O M PEREIRASMITH Dominance of In Vitro | 133 |
E KESHET A ITIN and G ROTMAN Retroviruslike Gene Families | 149 |
P S MILLER C H AGRIS L AURELIAN K R BLAKE S B LIN | 215 |
J WHANGPENG E LEE C S KAOSHAN R BOCCIA | 233 |
BOREK Critical Molecular Events and Gene Regulation | 255 |
F RAJEWSKY J ADAMKIEWICZ N HUH A KINDLERROHRBORN | 267 |
S B PRUSINER Structure and Biology of Scrapie Prions 277 | 289 |
H PIETTE Ageing and Cancer A Common Free Radical | 300 |
P P CARBONE C BEGG and J MOORMAN Cancer in | 313 |
Cellular studies on | 325 |
A PEARLMAN S R HOLBROOK and S H KIM The Conforma | 162 |
Initiation and Propagation 183 | 182 |
Index | 341 |
Other editions - View all
Common terms and phrases
Acad activity altered amplification Biochem Biol biological Ca2+ medium cancer Cancer and Differentiation Cancer Res carcinogenesis carcinogens cell cultures cell lines cell types chemical chromosome clonal clones crosslink disease E1A products EC cells elderly patients embryonal carcinoma enhancer enzyme epidermal fetal fibroblast fragile sites frequency function gene expression genetic genome growth factor heterogeneity high Ca2+ human cells hybridization increase induced inhibition initiated interaction Interrelationship Among Aging isolated lanes lectins lymphocytes malignant mechanisms membrane metastases methylation molecular mouse mRNA mutations myeloma Natl neoplastic normal nucleic acid observed occur oligomer oncogenes pE1ASV phenotype phorbol ester prions probes Proc proliferation proliferative protein proto-oncogenes Prusiner psoralen recombinant Reidel Publishing Company retrovirus-like Sachs sarcoma scrapie senescence sequences shown Southern blot specific structure studies supercoiling Syrian hamster thymine tissue topoisomerase transcription transfected transformation treatment tumor cells tumor promoters viral viruses vitro vivo