Interrelationship Among Aging, Cancer and Differentiation: Proceedings of the Eighteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, April 29–May 2, 1985A. Pullman, Paul O.P. Ts'O, Edward L. Schneider Springer Science & Business Media, 2012 M12 6 - 345 pages In 1980. a distinguished group of scientists gathered In Washington. D. C. for an International Symposium on Aging and Cancer. Among the recommendations of this Symposium was to convene a future meeting to discuss the molecular basis for Interrelationships between aging and cancer when the appropriate scientific knowledge was available. That same year. the 13th Jerusalem Symposium on Quantum Chemistry and Biochemistry entitled ·Carcl nogenesls : Fundamental Mechanisms and Environmental Effects·. was held. attended by some 50 International authorities In this field. At this meeting. It became clear that the fundamental process of carcinogenesis 15 Intimately associated with differentiation. which must also be mechanistically related to aging. It was therefore proposed that the next Jerusalem Symposium on Cancer could provide the appropriate forum for the study on the Interrelationship among cancer. aging and differentiation. The Impressive advances In our knowledge of the nature of the genome through molecular genetic and physical chemical techniques have now provided the opportunity to examine the Interrelationships between these complex biolo gical processes. Through the Isolation. cloning and rearranging of genes we are able to dissect and manipulate the genome In a fashion that was unanticipated only a decade ago. At the same time. the Increase In longevity and the Increased numbers of Individuals entering the last decades of life where cancer Incidences are highest raise the profound and practical question of whether aging and cancer are linked through common mechanisms. |
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Page 3
... observed in man . age ; often What can we learn from cell biology about the interrelationships between aging , cancer and differentiation ? Human diploid cells in tissue culture have three choices : they can differentiate or these ...
... observed in man . age ; often What can we learn from cell biology about the interrelationships between aging , cancer and differentiation ? Human diploid cells in tissue culture have three choices : they can differentiate or these ...
Page 9
... observation ( figure 1 ) that cancer mortality rose and then leveled off at a time in life when deaths from all causes rose ... observed PERCENT OF ALL DEATHS 80 70 60 50 40 30 DECELERATION OF CANCER MORTALITY RATES WITH AGE AND TIME 9.
... observation ( figure 1 ) that cancer mortality rose and then leveled off at a time in life when deaths from all causes rose ... observed PERCENT OF ALL DEATHS 80 70 60 50 40 30 DECELERATION OF CANCER MORTALITY RATES WITH AGE AND TIME 9.
Page 11
... observed trend could be explained purely by cumulative phenomena . Apparently , most carcinogens become pathogenic under specific and , as yet , poorly understood circumstances . These data could indicate the existence of protective ...
... observed trend could be explained purely by cumulative phenomena . Apparently , most carcinogens become pathogenic under specific and , as yet , poorly understood circumstances . These data could indicate the existence of protective ...
Page 17
... observed more closely for histologic type one finds that elderly individuals have a dispropor- tionate occurrence of anaplastic carcinoma compared to follicular and papillary carcinoma which occur to a greater extent in the younger ...
... observed more closely for histologic type one finds that elderly individuals have a dispropor- tionate occurrence of anaplastic carcinoma compared to follicular and papillary carcinoma which occur to a greater extent in the younger ...
Page 19
... observed for older compared with younger patients . On the other hand , in the treatment of acute myelogenous leukemia wherein much more intense therapy has been utilized , there is much more striking impact on bone marrow function and ...
... observed for older compared with younger patients . On the other hand , in the treatment of acute myelogenous leukemia wherein much more intense therapy has been utilized , there is much more striking impact on bone marrow function and ...
Contents
15 | |
MARTIN Overview of the Pathobiology of Aging 23 | 35 |
G B PIERCE and R S WELLS Cancer Cells as Probes of Embryonic | 59 |
S H YUSPA Alterations in Epidermal Differentiation in Skin Carcino | 80 |
J A MOSHIER R A MORGAN and R C C HUANG Expression | 100 |
R T SCHIMKE Methotrexate Resistance Gene Amplification | 117 |
J R SMITH and O M PEREIRASMITH Dominance of In Vitro | 133 |
E KESHET A ITIN and G ROTMAN Retroviruslike Gene Families | 149 |
P S MILLER C H AGRIS L AURELIAN K R BLAKE S B LIN | 215 |
J WHANGPENG E LEE C S KAOSHAN R BOCCIA | 233 |
BOREK Critical Molecular Events and Gene Regulation | 255 |
F RAJEWSKY J ADAMKIEWICZ N HUH A KINDLERROHRBORN | 267 |
S B PRUSINER Structure and Biology of Scrapie Prions 277 | 289 |
H PIETTE Ageing and Cancer A Common Free Radical | 300 |
P P CARBONE C BEGG and J MOORMAN Cancer in | 313 |
Cellular studies on | 325 |
A PEARLMAN S R HOLBROOK and S H KIM The Conforma | 162 |
Initiation and Propagation 183 | 182 |
Index | 341 |
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Acad activity altered amplification Biochem Biol biological Ca2+ medium cancer Cancer and Differentiation Cancer Res carcinogenesis carcinogens cell cultures cell lines cell types chemical chromosome clonal clones crosslink disease E1A products EC cells elderly patients embryonal carcinoma enhancer enzyme epidermal fetal fibroblast fragile sites frequency function gene expression genetic genome growth factor heterogeneity high Ca2+ human cells hybridization increase induced inhibition initiated interaction Interrelationship Among Aging isolated lanes lectins lymphocytes malignant mechanisms membrane metastases methylation molecular mouse mRNA mutations myeloma Natl neoplastic normal nucleic acid observed occur oligomer oncogenes pE1ASV phenotype phorbol ester prions probes Proc proliferation proliferative protein proto-oncogenes Prusiner psoralen recombinant Reidel Publishing Company retrovirus-like Sachs sarcoma scrapie senescence sequences shown Southern blot specific structure studies supercoiling Syrian hamster thymine tissue topoisomerase transcription transfected transformation treatment tumor cells tumor promoters viral viruses vitro vivo