Interrelationship Among Aging, Cancer and Differentiation

Front Cover
A. Pullman, Bernard Pullman, Paul O.P. Ts'O, Edmond L. Schneider, Edward L. Schneider
Springer Science & Business Media, 1985 M11 30 - 345 pages
In 1980. a distinguished group of scientists gathered In Washington. D. C. for an International Symposium on Aging and Cancer. Among the recommendations of this Symposium was to convene a future meeting to discuss the molecular basis for Interrelationships between aging and cancer when the appropriate scientific knowledge was available. That same year. the 13th Jerusalem Symposium on Quantum Chemistry and Biochemistry entitled ·Carcl nogenesls : Fundamental Mechanisms and Environmental Effects·. was held. attended by some 50 International authorities In this field. At this meeting. It became clear that the fundamental process of carcinogenesis 15 Intimately associated with differentiation. which must also be mechanistically related to aging. It was therefore proposed that the next Jerusalem Symposium on Cancer could provide the appropriate forum for the study on the Interrelationship among cancer. aging and differentiation. The Impressive advances In our knowledge of the nature of the genome through molecular genetic and physical chemical techniques have now provided the opportunity to examine the Interrelationships between these complex biolo gical processes. Through the Isolation. cloning and rearranging of genes we are able to dissect and manipulate the genome In a fashion that was unanticipated only a decade ago. At the same time. the Increase In longevity and the Increased numbers of Individuals entering the last decades of life where cancer Incidences are highest raise the profound and practical question of whether aging and cancer are linked through common mechanisms.

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Contents

DECELERATION OF CANCER MORTALITY RATES WITH AGE AND TIME
7
CLINICAL ASPECTS OF CANCER IN THE ELDERLY
15
OVERVIEW OF THE PATHOBIOLOGY OF AGING
23
REGULATORS OF GROWTH DIFFERENTIATION AND THE REVERSAL OF MALIGNANCY
35
TRANSFORMING GENES OF HUMAN MALIGNANCIES
43
CANCER CELLS AS PROBES OF EMBRYONIC DEVELOPMENT
59
ALTERATIONS IN EPIDERMAL DIFFERENTIATION IN SKIN CARCINOGENESIS
67
VIRUS TRANSFORMATION AS A FUNCTION OF AGE DIFFERENTIATION AND
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Tissue
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AGEING AND CANCER
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my
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then this
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the
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CELLULAR STUDIES ON THE INTERRELATIONSHIP AMONG CANCER AGING AND
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INDEX
341
SERIES EDITORS PREFACE
v

EXPRESSION OF TWO MURINE GENE FAMILIES IN TRANSFORMED CELLS AND
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ill
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taell
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METHOTREXATE RESISTANCE GENE AMPLIFICATION AND SOMATIC CELL
117
MACROMOLECULAR CORRELATES OF CELLULAR SENESCENCE AND CANCER
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21
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06
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DOMINANCE OF IN VITRO SENESCENCE IN SOMATIC CELL HYBRIDIZATION AND
133
COLLAGEN
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sky
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1
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The Conformational Effects of UV Induced Damage on DNA
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cooth
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W
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DNA SUPERCOILING AND GENE EXPRESSION
173
INTERMEDIATES IN TRANSCRIPTION INITIATION AND PROPAGATION
183
Fig 2
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A
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Figure 6
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CRITICAL MOLECULAR EVENTS AND GENE REGULATION IN CARCINOGENESIS
255
MONOCLONAL ANTIBODIES DIRECTED AGAINST ALKYLDEOXYNUCLEOSIDES AND CELL
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500
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STRUCTURE AND BIOLOGY OF SCRAPIE PRIONS
277
VIRAL GENES AND PERTURBATION OF DIFFERENTIATED
289
ப்பாய்
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I would like to thank the Reidel Publishing Company and
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Figure 6
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Figure 11
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CHAPTER 5
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CHAPTER 6
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C+E
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İXİA
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IMYY
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2
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3
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10
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REFERENCES
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